Research library / Resveratrol and sirtuins

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

K Howitz, K Bitterman, H Cohen, D Lamming, S Lavu, J Wood et al.. Nature. 2003.

Published 2026-10-15Sources checked 2026-10-151 sourceEverstack research teamHow we work

In plain language

Reported that resveratrol activates sirtuins and extended yeast lifespan by 70%.

Limits

Later work tied part of the activation to an assay artifact.

Source

doi.org/10.1038/nature01960 · PubMed 12939617

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