Everstack Evidence
Plain-language summaries of the research behind common longevity supplements. Including null results, and ingredients we do not sell.
Editorial section. Research summaries are not product claims and contain no product links or offers. A summary is never proof that any product works.
Human skeletal muscle under an electron microscope.
Every grade starts here: what happens in real human tissue, and what we do not know yet.
Elite vs low treadmill fitness: adjusted hazard ratio for death 0.20, with no observed upper limit of benefit (association, 122,007 adults). association Mandsager K, et al (2018)
How we grade evidence
Creatine: strength, muscle and the aging body
Does creatine plus resistance training improve strength and lean mass, including in older adults?
3 sources · Last reviewed 2026-10-14
Omega-3: what the largest trial did and did not show
What does high-quality evidence say about marine omega-3 supplements in healthy adults?
2 sources · Last reviewed 2026-10-14
Vitamin D: fill the gap, skip the hype
Who benefits from vitamin D3, and what did large trials find in healthy adults?
2 sources · Last reviewed 2026-10-14
Magnesium and sleep: promising, not proven
Does oral magnesium improve sleep?
2 sources · Last reviewed 2026-10-14
Glycine, L-theanine and apigenin: the evening trio
What is the human evidence for each ingredient in our PM stack?
2 sources · Last reviewed 2026-10-14
NR and NMN: raising NAD+ is not the same as slowing aging
Do NAD+ precursors raise NAD+ in people, and does that change how people function?
2 sources · Last reviewed 2026-10-14
Protein: the dose that matters for muscle
How much protein supports muscle gains from resistance training?
1 sources · Last reviewed 2026-10-14
Berberine and glucose metabolism
What do controlled human studies and meta-analyses show about berberine and markers of glucose and lipid metabolism?
6 sources · Last reviewed 2026-10-15
Nicotinamide riboside (NR) in human trials
Does oral NR raise NAD+ in people, and does that change health markers?
3 sources · Last reviewed 2026-10-15
NMN in human trials
What do controlled human studies of nicotinamide mononucleotide (NMN) show?
2 sources · Last reviewed 2026-10-15
Resveratrol and sirtuins: the scientific debate
Does resveratrol directly activate SIRT1, the 'longevity enzyme'?
4 sources · Last reviewed 2026-10-15
Resveratrol: mice, lifespan and people
Does resveratrol extend lifespan in mammals or relate to longevity in humans?
4 sources · Last reviewed 2026-10-15
Omega-3 and heart outcomes: why the big trials disagree
Do omega-3 supplements reduce major cardiovascular events?
3 sources · Last reviewed 2026-10-15
The Omega-3 Index
What is the Omega-3 Index and why do some experts track it?
1 sources · Last reviewed 2026-10-15
Vitamin D: what the largest trials found
In adults who are not deficient, does vitamin D supplementation reduce fractures, mortality or functional decline?
3 sources · Last reviewed 2026-10-15
Magnesium and sleep in older adults
Does oral magnesium help older adults fall asleep?
1 sources · Last reviewed 2026-10-15
Rapamycin and mTOR: the strongest mouse lifespan data
Does rapamycin extend lifespan, and what is known in people?
3 sources · Last reviewed 2026-10-15
Metformin and the TAME trial
Why do researchers want to test metformin as an aging drug?
1 sources · Last reviewed 2026-10-15
The fasting-mimicking diet
Do periodic 5-day low-calorie cycles change markers linked to aging?
1 sources · Last reviewed 2026-10-15
Cardiorespiratory fitness and long-term mortality
How strongly is aerobic fitness linked to how long people live?
1 sources · Last reviewed 2026-10-15
Protein needs after 65
How much protein do older adults need?
2 sources · Last reviewed 2026-10-15
Taurine and aging
Does taurine supplementation slow aging?
1 sources · Last reviewed 2026-10-15
Spermidine
What is the evidence for spermidine and longevity?
1 sources · Last reviewed 2026-10-15
Urolithin A and mitochondria
Is urolithin A safe and does it affect human muscle?
1 sources · Last reviewed 2026-10-15
Alpha-ketoglutarate (AKG)
Does AKG extend lifespan?
1 sources · Last reviewed 2026-10-15
Epigenetic clocks: measuring 'biological age'
What do DNA methylation clocks measure, and can they judge a supplement?
1 sources · Last reviewed 2026-10-15
Notes on the Blueprint protocol
How much of Bryan Johnson's Blueprint protocol is backed by trials?
4 sources · Last reviewed 2026-10-15
What the experts said
Verbatim public statements from researchers, with source, date and timestamp. Quoting someone does not mean they endorse Everstack, and they never appear on product pages.
Our first verified quotes publish with the launch brief. Every quote is checked word for word against the original recording or text before it appears.
- Verbatim only, with source, date and link
- No implied endorsement, ever
- Opposing views shown when experts disagree
- Corrections within 48 hours
Spot an error? Email hello@everstackhealth.com and we will correct it within 48 hours.