Everstack Evidence

The fasting-mimicking diet

One randomized crossover trial with marker endpoints; developer-affiliated.

Published 2026-10-15Sources checked 2026-10-151 sourceEverstack research teamHow we work

Editorial section. Research summaries are not product claims and contain no product links or offers. A summary is never proof that any product works.

The question

Do periodic 5-day low-calorie cycles change markers linked to aging?

Study design

100 generally healthy US adults randomized to 3 monthly 5-day cycles of a plant-based, low-calorie, low-protein diet or their usual diet. ^[1]

What they found

Three cycles reduced body weight, body fat, blood pressure and IGF-1, with larger improvements in people with higher baseline risk factors. No serious adverse effects were reported. ^[1]

Limitations

Short trial, marker outcomes, high dropout. The senior author founded a company that sells the diet kits.

What this does not mean

Fasting protocols are not right for everyone. People with diabetes, a history of eating disorders, or who are pregnant should not try them without medical supervision.

Sources

1. Wei M et al. Sci Transl Med. 2017;9(377):eaai8700. doi.org/10.1126/scitranslmed.aai8700

Spot an error? Email hello@everstackhealth.com and we will correct it within 48 hours.