Research pillar

Who we read

Fifteen researchers, clinicians and communicators whose work we follow, and where our evidence grades agree or differ with theirs.

Important: No person, company, program or podcast named here endorses or is affiliated with Everstack. This is a research section: it does not sell or link to products.

Exact quotes are copied word for word from the linked source; where we could not verify exact wording we label it a paraphrase. Profiles verified 2026-10-15.

David Sinclair, PhD

Professor of Genetics, Harvard Medical School; co-founder, Life Biosciences

Studies sirtuins, NAD+ and epigenetic reprogramming. His information theory of aging underpins Life Biosciences' ER-100 trial. Co-author of the 2003 resveratrol-sirtuin paper that was later disputed.

Exact quote "Our research has suggested that aging is driven in large part by the loss of epigenetic information, not irreversible damage."

Our grades vs. their view: We grade NAD+ precursors C and resveratrol D for human outcomes; his public enthusiasm for both runs ahead of the controlled human data we cite. On reprogramming we agree it is the most interesting frontier, and still preclinical or phase 1.

X · Lab · Lifespan podcast

Peter Attia, MD

Physician; host of The Drive; author of Outlive

Focuses on exercise, nutrition, sleep and emotional health for healthspan, with heavy emphasis on VO2max and strength.

Paraphrase most supplements have modest or unproven effects, and exercise, sleep and nutrition matter far more.

Our grades vs. their view: Close agreement on exercise as the highest-yield lever (see Training for lifespan). He discusses rapamycin more openly than we do; we leave it out as a prescription drug.

X · Site · YouTube

Andrew Huberman, PhD

Professor of Neurobiology, Stanford; host of Huberman Lab

Hosts one of the most listened-to science podcasts, covering sleep, light, exercise and supplements.

Paraphrase behavioral tools such as morning light, consistent timing and temperature come before any sleep supplement.

Our grades vs. their view: Some sleep compounds he popularized (apigenin, L-theanine) carry only C grades from us: small trials, mostly subjective outcomes.

X · Site · YouTube

Rhonda Patrick, PhD

Biomedical scientist; founder of FoundMyFitness

Covers micronutrients, omega-3, vitamin D, sauna and exercise, often with researchers as guests.

Paraphrase many people fall short on key micronutrients, and blood levels are a better guide than intake guesses.

Our grades vs. their view: She leans on the Omega-3 Index and blood-level data; we grade omega-3 for heart outcomes more cautiously given null trials (VITAL, STRENGTH, ASCEND).

X · Site · YouTube

Matt Kaeberlein, PhD

Biologist of aging; former professor, University of Washington

Co-led the Dog Aging Project and published key work questioning resveratrol's activation of sirtuins.

Exact quote "In light of these findings, the mechanism accounting for putative longevity effects of resveratrol should be reexamined."

Our grades vs. their view: Agrees with our low resveratrol grade. More optimistic than us about rapamycin in people; we keep it out as an Rx drug.

X

Valter Longo, PhD

Professor of Gerontology, USC; developer of the fasting-mimicking diet

Researches fasting, nutrient sensing and aging. Has a financial interest in a fasting-mimicking diet company.

Exact quote "Larger studies in patients with diagnosed diseases or selected on the basis of risk factors are warranted to confirm the effect of the FMD on disease prevention and treatment."

Our grades vs. their view: We grade the fasting-mimicking diet C: one 100-person trial on risk markers, developer-affiliated.

X · Site

Eric Topol, MD

Cardiologist; founder of Scripps Research Translational Institute

Writes Ground Truths and the book Super Agers; focuses on evidence-based prevention, genomics and AI in medicine.

Paraphrase healthy aging is driven mostly by exercise, diet, sleep and avoiding risks, not by supplements.

Our grades vs. their view: Shares our skepticism of supplement hype and our emphasis on randomized trials over biomarkers.

X · Ground Truths

Andrew Steele, PhD

Scientist and author of Ageless

Computational biologist turned science communicator; explains aging biology and evaluates longevity claims on YouTube.

Paraphrase treating aging itself could prevent many diseases at once, but most products marketed for aging are not yet supported by human trials.

Our grades vs. their view: Like us, separates promising mouse data from proven human benefit.

X · Site · YouTube

Layne Norton, PhD

Nutrition scientist and powerlifter; founder of BioLayne

Known for evidence-focused commentary on protein, energy balance and training.

Paraphrase creatine is one of the few supplements with strong evidence; most results come from training, protein and calories.

Our grades vs. their view: Aligned with our A grade for creatine and our protein targets.

X · Site

Stuart Phillips, PhD

Professor of Kinesiology, McMaster University

Leading researcher on protein, resistance training and muscle in aging.

Exact quote "Dietary protein supplementation significantly enhanced changes in muscle strength and size during prolonged RET in healthy adults."

Our grades vs. their view: Our protein guidance follows his group's meta-analysis.

X · Faculty page

Nir Barzilai, MD

Director, Institute for Aging Research, Albert Einstein College of Medicine

Studies centenarians and leads efforts to run the TAME metformin trial.

Exact quote "Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial"

Our grades vs. their view: We do not offer metformin (Rx) and grade its case as a longevity drug D until TAME or similar trials report.

X

Eric Verdin, MD

President and CEO, Buck Institute for Research on Aging

Researches NAD+ metabolism, sirtuins and immune aging.

Paraphrase NAD+ levels decline with age, and whether restoring them benefits humans still needs controlled trials.

Our grades vs. their view: His NAD+ biology work supports the mechanism behind our NR pick; human outcome data remain thin, hence grade C.

Lab

Darren Candow, PhD

Professor, University of Regina; creatine researcher

Studies creatine and resistance training in aging adults.

Exact quote "creatine supplementation increases lean tissue mass and upper and lower body muscular strength during resistance training of older adults"

Our grades vs. their view: Our A grade for creatine with training matches his meta-analyses.

X

Brad Stanfield, MD

Primary care physician, New Zealand; YouTube educator

Reviews longevity supplements and trials for a general audience.

Paraphrase base supplement choices on randomized trials in humans, not mouse studies.

Our grades vs. their view: Similar trial-first approach; he sells his own supplements, which we note as a potential conflict.

X · YouTube

Bryan Johnson

Entrepreneur; founder of Blueprint

Publishes his personal longevity protocol and biomarkers. Not a scientist; his data are n-of-1 and he sells products.

Paraphrase his protocol is built on measuring his own biomarkers and adjusting based on the data.

Our grades vs. their view: We read Blueprint as an experiment, not evidence: one person, many simultaneous interventions, commercial interest.

X · Protocol