Everstack Evidence

Rapamycin and mTOR: the strongest mouse lifespan data

Robust, replicated mouse lifespan extension; human evidence is limited to immune and safety studies. Prescription drug, not a supplement.

Published 2026-10-15Sources checked 2026-10-153 sourcesEverstack research teamHow we work

Editorial section. Research summaries are not product claims and contain no product links or offers. A summary is never proof that any product works.

The question

Does rapamycin extend lifespan, and what is known in people?

Study design

NIA Interventions Testing Program at three sites (2009); a randomized trial of an mTOR inhibitor and vaccine response in older adults (2014). ^[1][2][3]

What they found

Rapamycin started at the mouse equivalent of about 60 human years extended median and maximum lifespan in both sexes. In older adults, a short course of an mTOR inhibitor improved flu vaccine response. ^[1][2][3]

Limitations

No human lifespan data. Side effects and dosing for healthy people are unresolved.

What this does not mean

This is context for the field, not a recommendation. Rapamycin requires a prescriber.

Sources

1. Harrison DE et al. Nature. 2009;460:392-395. doi.org/10.1038/nature08221
2. Mannick JB et al. Sci Transl Med. 2014;6(268):268ra179. doi.org/10.1126/scitranslmed.3009892
3. Miller RA et al. J Gerontol A. 2011;66(2):191-201. doi.org/10.1093/gerona/glq178

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