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Urolithin A and mitochondria

Early human trials with molecular endpoints; developer-funded.

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Human fibroblasts, fluorescence: mitochondria in red, nuclei in blue, nanoparticles in green
Human fibroblasts, fluorescence: mitochondria in red, nuclei in blue, nanoparticles in green. Image: Matteo Battaglini, CC BY 4.0

Editorial section. Research summaries are not product claims and contain no product links or offers. A summary is never proof that any product works.

The question
Is urolithin A safe and does it affect human muscle?
Study design
First-in-human randomized, placebo-controlled trial in healthy older adults (2019). [1]
What they found
Urolithin A was well tolerated and produced a molecular signature consistent with improved mitochondrial and cellular health in muscle. [1]
Limitations
Molecular markers, short duration, funded by the company that developed it.
What this does not mean
Better markers do not yet equal better strength or longevity.
Sources
  1. Andreux PA et al. Nat Metab. 2019;1:595-603. doi.org/10.1038/s42255-019-0073-4

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